Research papers on Hydrogen & Gut Health

Lian N, Shen M, Zhang K, Pan J, Jiang Y, Yu Y, Yu Y. Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. J Pain Res. 2021;14:681-691

Zhang X, Tao G, Zhao Y, et al. Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway. BioMed Research International. 2022;2022:e8024452. doi:


Ostojic SM. Hydrogen-rich water as a modulator of gut microbiota? Journal of Functional Foods. 2021;78:104360. doi:

Kajiya M, Silva MJB, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochemical and Biophysical Research Communications. 2009;386(1):11-15. doi:


Hirano S, Yamamoto H, Ichikawa Y, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression. International Journal of Molecular Sciences. 2021;22(16):8724. doi:

Ge L, Qi J, Shao B, et al. Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier. Gut Microbes. 2022;14(1). doi:

Han Q, Bai Y, Zhou Chunjing, et al. Effect of molecular hydrogen treatment on Sepsis‐Associated encephalopathy in mice based on gut microbiota. CNS Neuroscience & Therapeutics. 2022;29(2):633-645. doi:

Akita Y, Masaaki Higashiyama, Kurihara C, et al. Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids. Digestive Diseases and Sciences. 2022;68(5):1824-1834. doi:

Hu D, Huang T, Shigeta M, et al. Electrolyzed Hydrogen Water Alleviates Abdominal Pain through Suppression of Colonic Tissue Inflammation in a Rat Model of Inflammatory Bowel Disease. Nutrients. 2022;14(21):4451. doi:

Du D, Zhao L, Shen M, et al. Hydrogen medicine: A rising star in gas medicine. Traditional medicine and modern medicine. 2020;03(03):153-161. doi:

Panayotova S. Hydrogen to patients with colon cancer» HHO Bulgaria. HHO Bulgaria. Published August 1, 2022. Accessed December 3, 2023.

Xu KC, Chen JB, Kong XF, et al. “Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients. Medical Gas Research. 2019;9(3):115. doi:

Zhu B, Cui H, Xu W. Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis. Cancer Cell International. 2021;21(1). doi:

Chu J, Gao J, Wang J, et al. Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing. Oncology Reports. 2021;46(1):141. doi:

Chen JB, Lu YY, Xu KC. A narrative review of hydrogen oncology: from real world survey to real world evidence. Medical Gas Research. 2020;10(3):0. doi:

Mohd Noor MNZ, Alauddin AS, Wong YH, et al. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pacific Journal of Cancer Prevention. 2023;24(1):37-47. doi:

Tian Y, Zhang Y, Wang Y, et al. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Frontiers in Physiology. 2021;12. doi:

Yang Q, Ji G, Pan R, Zhao Y, Yan P. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Molecular and Clinical Oncology. 2017;7(5):891-896. doi:\
Akagi J, Baba H. Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. Oncology Reports. Published online November 1, 2018. doi: