Hydrogen & Gut Health

Lian N, Shen M, Zhang K, Pan J, Jiang Y, Yu Y, Yu Y. Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. J Pain Res. 2021;14:681-691https://doi.org/10.2147/JPR.S288289

Zhang X, Tao G, Zhao Y, et al. Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway. BioMed Research International. 2022;2022:e8024452. doi:https://doi.org/10.1155/2022/8024452


Ostojic SM. Hydrogen-rich water as a modulator of gut microbiota? Journal of Functional Foods. 2021;78:104360. doi:https://doi.org/10.1016/j.jff.2021.104360

Kajiya M, Silva MJB, Sato K, Ouhara K, Kawai T. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochemical and Biophysical Research Communications. 2009;386(1):11-15. doi:https://doi.org/10.1016/j.bbrc.2009.05.117


Hirano S, Yamamoto H, Ichikawa Y, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression. International Journal of Molecular Sciences. 2021;22(16):8724. doi:https://doi.org/10.3390/ijms22168724

Ge L, Qi J, Shao B, et al. Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier. Gut Microbes. 2022;14(1). doi:https://doi.org/10.1080/19490976.2021.2013764

Han Q, Bai Y, Zhou Chunjing, et al. Effect of molecular hydrogen treatment on Sepsis‐Associated encephalopathy in mice based on gut microbiota. CNS Neuroscience & Therapeutics. 2022;29(2):633-645. doi:https://doi.org/10.1111/cns.14043

Akita Y, Masaaki Higashiyama, Kurihara C, et al. Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids. Digestive Diseases and Sciences. 2022;68(5):1824-1834. doi:https://doi.org/10.1007/s10620-022-07781-5

Hu D, Huang T, Shigeta M, et al. Electrolyzed Hydrogen Water Alleviates Abdominal Pain through Suppression of Colonic Tissue Inflammation in a Rat Model of Inflammatory Bowel Disease. Nutrients. 2022;14(21):4451. doi:https://doi.org/10.3390/nu14214451

Du D, Zhao L, Shen M, et al. Hydrogen medicine: A rising star in gas medicine. Traditional medicine and modern medicine. 2020;03(03):153-161. doi:https://doi.org/10.1142/s2575900020300052

Panayotova S. Hydrogen to patients with colon cancer» HHO Bulgaria. HHO Bulgaria. Published August 1, 2022. Accessed December 3, 2023. https://hho-ulgaria.com/en/hydrogen-colon-cancer/

Xu KC, Chen JB, Kong XF, et al. “Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients. Medical Gas Research. 2019;9(3):115. doi:https://doi.org/10.4103/2045-9912.266985

Zhu B, Cui H, Xu W. Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis. Cancer Cell International. 2021;21(1). doi:https://doi.org/10.1186/s12935-020-01743-5

Chu J, Gao J, Wang J, et al. Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing. Oncology Reports. 2021;46(1):141. doi:https://doi.org/10.3892/or.2021.8092

Chen JB, Lu YY, Xu KC. A narrative review of hydrogen oncology: from real world survey to real world evidence. Medical Gas Research. 2020;10(3):0. doi:https://doi.org/10.4103/2045-9912.296044

Mohd Noor MNZ, Alauddin AS, Wong YH, et al. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pacific Journal of Cancer Prevention. 2023;24(1):37-47. doi:https://doi.org/10.31557/apjcp.2023.24.1.37

Tian Y, Zhang Y, Wang Y, et al. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Frontiers in Physiology. 2021;12. doi:https://doi.org/10.3389/fphys.2021.789507

Yang Q, Ji G, Pan R, Zhao Y, Yan P. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Molecular and Clinical Oncology. 2017;7(5):891-896. doi:https://doi.org/10.3892/mco.2017.1409\
Akagi J, Baba H. Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. Oncology Reports. Published online November 1, 2018. doi:https://doi.org/10.3892/or.2018.6841