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Molecular Hydrogen and Cancer

Molecular Hydrogen and Cancer

Molecular hydrogen as a potential adjunctive treatment for cancer

 

In recent years, has been growing interest in the potential of H2 therapy for the treatment of cancer. H2 has a number of properties that make it a promising cancer treatment:

Click here for H2 & Cancer research papers

Antioxidant

It is a powerful antioxidant, meaning that it can help to protect cells from damage caused by free radicals. Free radicals are unstable molecules that can damage DNA and other cellular structures. They are thought to play a role in the development of cancer.

Hydrogen can help to reduce oxidative stress, which can damage cells and contribute to the development of cancer.

Anti-inflammatory

H2 also has anti-inflammatory effects. Inflammation is a process that can contribute to the growth and spread of cancer. H2 can help to reduce inflammation by inhibiting the production of pro-inflammatory cytokines.

Hydrogen's anti-inflammatory effects may help to reduce the growth and spread of cancer.

Anti-apototic

In addition, H2 has been shown to have anti-apoptotic effects. Apoptosis is a natural process of cell death that is essential for maintaining the health of the body. Cancer cells often evade apoptosis, which allows them to survive and multiply. H2 can help to induce apoptosis in cancer cells, which can lead to their death.

Reduce Radiotherapy and Chemotherapy side effects

Evidence from research studies indicates that hydrogen therapy can help to protect cells from damage caused by chemotherapy and radiation therapy.

 

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Two main mechanisms of hydrogen (H2) cancer control.                                  Note: PD-1: Programmed cell death protein 1.

A narrative review of hydrogen oncology: from real world survey to real world evidence

Scientific Studies

There have been a number of studies that have investigated the potential of H2 therapy for the treatment of cancer. These studies have shown that H2 can be effective in inhibiting the growth of cancer cells in vitro and in vivo. In some cases, H2 has been shown to be as effective as traditional cancer treatments, such as chemotherapy and radiation therapy.

However, more research is needed to fully understand the potential of H2 therapy for the treatment of cancer. Currently, H2 therapy is not a standard treatment for cancer. However, it is a promising area of research and there is potential for H2 to be used as an adjunct therapy or as a way to reduce the side effects of traditional cancer treatments.

Below is the summary of a scientific paper in 2019 

Li S, Liao R, Sheng X, Luo X, Zhang X, Wen X, Zhou J, Peng K. Hydrogen Gas in Cancer Treatment. Front Oncol. 2019 Aug 6;9:696. 

Recently, hydrogen gas (H2) has gained attention for its potential in cancer treatment. Studies have shown that hydrogen gas can reduce the side effects of chemotherapy, inhibit the growth of cancer cells, and even suppress tumor growth in animal models. The mechanisms of action involve the regulation of reactive oxygen species (ROS), inflammation, and apoptosis. Hydrogen gas selectively scavenges harmful ROS, induces antioxidant enzymes to eliminate ROS, and modulates inflammatory cytokines. It can also regulate apoptosis by impacting the expression of apoptosis-related enzymes. Furthermore, hydrogen gas has been found to relieve the adverse effects of chemotherapy and radiotherapy, such as oxidative stress and inflammation. It has shown protective effects on the heart, liver, and kidneys in animal studies.

However, it is important to note that more research is needed to fully understand the potential of molecular hydrogen for cancer treatment. Currently, it is not a standard treatment for cancer. However, it is a promising area of research and there is potential for molecular hydrogen to be used as an adjunct therapy or as a way to reduce the side effects of traditional cancer treatments.

 Click here to buy H Fizz H2 products to support cancer therapy & recovery

 

To further explore, below are scientific studies on molecular hydrogen and cancer for your reference:

Lian N, Shen M, Zhang K, Pan J, Jiang Y, Yu Y, Yu Y. Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota. J Pain Res. 2021;14:681-691https://doi.org/10.2147/JPR.S288289

Li S, Liao R, Sheng X, Luo X, Zhang X, Wen X, Zhou J, Peng K. Hydrogen Gas in Cancer Treatment. Front Oncol. 2019 Aug 6;9:696. doi: 10.3389/fonc.2019.00696. PMID: 31448225; PMCID: PMC6691140.
Meng J, Liu L, Wang D, Yan Z, Chen G. Hydrogen gas represses the progression of lung cancer via down-regulating CD47. Biosci Rep. 2020 Apr 30;40(4):BSR20192761. doi: 10.1042/BSR20192761. PMID: 32314789; PMCID: PMC7189362. 
Kong X, Lu T, Lu YY, Yin Z, Xu K. Effect of Hydrogen Inhalation Therapy on Hearing Loss of Patients With Nasopharyngeal Carcinoma After Radiotherapy. Frontiers in Medicine. 2022;9. doi:https://doi.org/10.3389/fmed.2022.828370

 

Zhang X, Tao G, Zhao Y, et al. Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway. BioMed Research International. 2022;2022:e8024452. doi:https://doi.org/10.1155/2022/8024452

Xu KC, Chen JB, Kong XF, et al. “Real world survey” of hydrogen-controlled cancer: a follow-up report of 82 advanced cancer patients. Medical Gas Research. 2019;9(3):115. doi:https://doi.org/10.4103/2045-9912.266985

Zhu B, Cui H, Xu W. Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis. Cancer Cell International. 2021;21(1). doi:https://doi.org/10.1186/s12935-020-01743-5

Zhang X, Tao G, Zhao Y, et al. Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway. Gagat M, ed. BioMed Research International. 2022;2022:1-11. doi:https://doi.org/10.1155/2022/8024452

ND CD. Hydrogen as a Tool in the Fight to Reduce Cancer Treatment Side Effects. Today’s Practitioner. Published April 22, 2020. Accessed November 16, 2022. https://todayspractitioner.com/hydrogen/molecular-hydrogen-as-a-tool-in-the-fight-to-reduce-cancer-treatment-side-effects/#.Y3Rr3HYzaUk

Cole AR, Sperotto F, DiNardo JA, et al. Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults. Critical Care Explorations. 2021;3(10):e543. doi:https://doi.org/10.1097/CCE.000000000000054

Chen JB, Kong XF, Mu F, Lu TY, Lu YY, Xu KC. Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer. Medical Gas Research. 2020;10(2):75-80. doi:https://doi.org/10.4103/2045-9912.285560
Chu J, Gao J, Wang J, et al. Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing. Oncology Reports. 2021;46(1):141. doi:https://doi.org/10.3892/or.2021.8092

 

Chen J, Kong X, Mu F, Lu T, Du D, Xu K. Hydrogen-oxygen therapy can alleviate radiotherapy-induced hearing loss in patients with nasopharyngeal cancer. Annals of Palliative Medicine. 2019;8(5):746-751. doi:https://doi.org/10.21037/apm.2019.11.18

Hu Q, Zhou Y, Wu S, Wu W, Deng Y, Shao A. Molecular hydrogen: A potential radioprotective agent. Biomedicine & Pharmacotherapy. 2020;130:110589. doi:https://doi.org/10.1016/j.biopha.2020.110589
Chen JB, Kong XF, Qian W, et al. Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study. Medical Gas Research. 2020;10(4):149-154. doi:https://doi.org/10.4103/2045-9912.304221

 

Hirano SI, Aoki Y, Li XK, Ichimaru N, Takahara S, Takefuji Y. Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study. Medical Gas Research. 2021;11(3):104-109. doi:https://doi.org/10.4103/2045-9912.314329

Hirano S, Yamamoto H, Ichikawa Y, Sato B, Takefuji Y, Satoh F. Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression. International Journal of Molecular Sciences. 2021;22(16):8724. doi:https://doi.org/10.3390/ijms22168724

 

Chen JB, Lu YY, Xu KC. A narrative review of hydrogen oncology: from real world survey to real world evidence. Medical Gas Research. 2020;10(3):0. doi:https://doi.org/10.4103/2045-9912.296044

Mohd Noor MNZ, Alauddin AS, Wong YH, et al. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pacific Journal of Cancer Prevention. 2023;24(1):37-47. doi:https://doi.org/10.31557/apjcp.2023.24.1.37 

Tian Y, Zhang Y, Wang Y, et al. Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis. Frontiers in Physiology. 2021;12. doi:https://doi.org/10.3389/fphys.2021.789507

 

Yang Y, Zhu Y, Xi X. Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review). Oncology Letters. Published online June 26, 2018. doi:https://doi.org/10.3892/ol.2018.9023

Yang Y, Zhu Y, Xi X. Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review). Oncology Letters. Published online June 26, 2018. doi:https://doi.org/10.3892/ol.2018.9023

 

 

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